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KMID : 0931320160160020082
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대한상부위장관.헬리코박터학회지
2016 Volume.16 No. 2 p.82 ~ p.87
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The Influence of Iron Deficiency on Helicobacter pylori Eradication
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Kim Sung-Eun
Park Moo-In
Park Seun-Ja
Kim Jae-Hyun
Jung Kyoung-Won
Seo Kwang-Il
Lim Seong-Kyeong
Jung Jin-Kyu
Kim Hyeon-Jin
Yeo Go-Eun
Jeon Sung-Chan
Cho Duk-Song
Han You-Jin
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Abstract
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Background/Aims: Helicobacter pylori is a distinctive pathogen that lives in the gastric mucosa and is a well known risk factor of gastric adenocarcinoma. Iron deficiency aggravates the development of H. pylori-induced premalignant and malignant lesions in a cagA-dependent manner, enhancing H. pylori virulence. The aim of this study was to identify the relationship between iron deficiency and H. pylori eradication rates.
Materials and Methods: Participants who received 7 days of first-line triple therapy with serum iron level measured in parallel were retrospectively investigated between 2005 and 2014. H. pylori eradication was confirmed by the rapid urease test or 13C-urea breath test at least 4 weeks after completion of triple therapy. Iron deficiency was defined as either a serum iron level less than 50 μg/dL or a serum ferritin level less than 12 ng/mL.
Results: A total of 194 patients received 7 days of first-line triple therapy along with parallel serum iron level measurements over the 10-year period. The mean average age was 53.3 years (range, 21∼86 years), and 135 patients (69.6%) were male. The overall H. pylori eradication rate was 83.5%. Proportions of eradication success with ferritin level less than 12 ng/mL and iron less than 50 μg/dL were 90.5% and 88.6%, respectively. However, there was no statistical difference in eradication rates according to iron deficiency.
Conclusions: Iron deficiency might not be related with H. pylori eradication rates in this study. Further large-scale studies are needed to confirm this result.
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KEYWORD
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Helicobacter pylori, Disease eradication, Iron
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